Our incomplete understanding of carcinogenesis may be a significant reason why some cancer mortality rates are still increasing. This lack of understanding is likely due to a research approach that relies heavily on genetic comparison between cancerous and non‐cancerous tissues and cells, which has led to the identification of genes of cancer proliferation rather than differentiation. Recent observations showing that a tremendous degree of natural human genetic variation occurs are likely to lead to a shift in the basic paradigms of (...) cancer genetics, in that there is a need to consider both the nature of the genes involved, and the idea that not every genetic variation identified in these genes may be associated with carcinogenesis. Based on studies using LCM and micro‐genetic analyses, we propose that significant cancer initiating events may take place during the very early stages of development of cancer‐susceptible tissues and that using such techniques might greatly help us in our understanding of carcinogenesis. BioEssays 29:678–685, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This paper situates the subprime crisis in the context of the performance of the American economy over the last twenty-five years. The restructuring of the US economy is briefly reviewed, followed by an examination of some of the contradictions of the neoliberal model. Particular emphasis is placed on understanding the reasons behind stagnant investment, and how the US finance-led accumulation-régime has become dependent upon, and threatened by, credit-creation delinked from the financing of fixed-capital formation. I argue that while the defeat (...) of the remnants of the New-Deal/Civil-Rights liberal-democratic coalition has provided the political context for the bold re-assertion of the prerogatives of capitalist owners, the neoliberal model has not provided a path out of problems of stagnation and growing debt-dependency that presently plague the US economy. Further, I argue that evidence suggests that the post-1982 restoration of profitability that underpinned the relative improvement of US economic performance has peaked, and that compelling historical and theoretical reasons exist to expect that the profit-rate will decline in the coming decade. This will introduce additional stresses on the current debt-structure of the US economy, triggering a period of prolonged crisis and economic dislocation. The conclusion is that the US economy faces the spectre of a protracted crisis associated with the reassertion of the falling rate of profit. (shrink)

The dualism of nature/culture widely present within Western society at large is out of step with an increasingly urbanising world. Building on previous discussions of nature/culture duality, an integrative framework is presented that argues for the embracing of the 'mundane nature' found within human landscapes. As over half of the human population interacts with nature primarily within urban landscapes, increasing our awareness of such spaces is critical to understanding our ecological consciousness. The examples of a recent rooftop greening bylaw in (...) the city of Toronto and the social impacts of urban gardening are examined in this context. (shrink)

The creation of a sense of place has emerged as a goal of many community development initiatives. However, little thought has been given to the role of physical spaces in the shaping of possible senses of place. This article examines three Canadian examples of community sustainable development initiatives to demonstrate that sense of place can be shaped and constrained by the geographical and environmental features of the physical space a community occupies. This finding suggests that a 'one-size-fits-all' approach to community (...) sustainable development is unlikely to be successful; a community's sustainable development ethic will be informed by geography. However, there is some evidence that a strong individual sense of place shaped by local space may act as a barrier to the acceptance of new people and ideas. Conversely, a strong sense of place can result in mobilization for sustainable development initiatives. (shrink)

Americans have trillions of dollars invested in public and private companies, yet stock ownership is highly unequal: the wealthiest 1 percent of households possess 40 percent of all wealth, and there is a large and persistent racial wealth gap. What if innovations in distributed technologies allowed for democratic facilitation of new opportunities for wealth and a rebalancing of power within the capital markets? This article proposes using innovative financial technologies to create a “Public Investment Platform”—a public option for participation in (...) capital markets—and a “Public Investment Account” to universalize access to investment opportunities. Capital markets are currently governed by public policies that submerge the role of the public in structuring them and enable an inequitable accumulation of wealth. To democratize finance, new policies are required to democratize participation in investment. (shrink)

This article builds on the food sovereignty literature to ask pointed questions about the interplay of market forces and political liberalism. Specifically, we use cuisine as a lens to interrogate the assumption that multiculturalism is compatible with Indigenous food sovereignty. Because multicultural inclusion is the means by which Indigenous Peoples’ gastronomies are commodified and alienated, they experience not gastronomic multiculturalism but culinary colonialism. Accordingly, food sovereignty in colonial contexts must embrace both the active sharing and the mindful withholding of food (...) as political acts, and acknowledge that culinary culture is not simply a market commodity but also a politically-embedded process. In drawing together the threads of this argument, we advocate for a broadening of the discussion on Indigenous food sovereignty to include the resistance and resurgence enacted through gastronomy. (shrink)

This book provides an introduction to postphenomenology, an emerging school of thought in the philosophy of technology and science and technology studies, which addresses the relationships users develop with the devices they use.

How (Not) to Be Secular is what Jamie Smith calls "your hitchhiker's guide to the present" -- it is both a reading guide to Charles Taylor's monumental work A Secular Age and philosophical guidance on how we might learn to live in our times. Taylor's landmark book A Secular Age (2007) provides a monumental, incisive analysis of what it means to live in the post-Christian present -- a pluralist world of competing beliefs and growing unbelief. Jamie Smith's book is a (...) compact field guide to Taylor's insightful study of the secular, making that very significant but daunting work accessible to a wide array of readers. Even more, though, Smith's How (Not) to Be Secular is a practical philosophical guidebook, a kind of how-to manual on how to live in our secular age. It ultimately offers us an adventure in self-understanding and maps out a way to get our bearings in today's secular culture, no matter who "we" are -- whether believers or skeptics, devout or doubting, self-assured or puzzled and confused. This is a book for any thinking person to chew on. (shrink)

Concerned with criticizing representational theories of knowledge by developing alternative concepts of knowing and communicating, Ian Angus and Lenore Langsdorf bring together eight essays that are united by a common theme: the convergence of philosophy and rhetoric. In the first chapter, Angus and Langsdorf illustrate the centrality of critical reasoning to the nature of questioning itself, arguing that human inquiry has entered a "new situation" where "the convictions and orientations that have traditionally marked the separation of rhetoric and philosophy—the (...) concern for truth and the focus on persuasion—have begun to converge on a new space that can be defined through the central term _discourse._"_ _In these essays, this convergence of rhetoric and philosophy is addressed as it presents itself to a variety of interests that transcend the traditional boundaries of these fields. The two editors, Raymie E. McKerrow, Michael J. Hyde and Craig R. Smith, James W. Hikins and Kenneth S. Zagacki, Calvin O. Schrag and David James Miller, and Richard L. Lanigan map this new space, recognizing that such mapping "simultaneously _constitutes _the territory mapped.". (shrink)

In this essay, I analyze pregnancy loss from a feminist phenomenological perspective. I draw upon relational accounts of personhood wherein a person's status and identity are formed through a lived history and the activity of “calling into personhood” a being a woman may seek to know or become. I draw upon the work of Simone de Beauvoir, who advances a feminist phenomenology that grounds the status and identity of women within embodied situations. Her important work sheds light on the varied (...) perceptions and processes that inform experiences of pregnancy and pregnancy loss. (shrink)

While widely acknowledged as the world's oldest profession, and often glamorized or demonized in the media, prostitution is a critical part of American culture and its economy, as well as a social problem in need of an updated public policy. In Prostitution Policy, Lenore Kuo combines feminist social research and legal studies to tackle issues raised by heterosexual prostitution in the U.S. Through the lens of feminist theory, Kuo examines the milieu of prostitutes and the role of prostitution in (...) contemporary society, and how the interplay of those two works itself out in practice. Moving beyond theoretical analysis of prostitution, Prostitution Policy turns to the complicated problem of formulating a reasonable legal policy that minimizes harm. Kuo discusss criminalization, legalization, and decriminalization as possible approaches, ultimately arguing for a unique form of decriminalization including detailed legal oversight and mandatory social services. (shrink)

Ethical problems are addressed in various ways within countries in planning for and response to pandemic influenza. Here we report on a qualitative study, in which 46 policymakers in Malawi and Ghana were interviewed on how they identified and resolved ethical problems. The study results revealed that ethical problems involving conflicts of values and choices were raised in reference to the extent and role of resources and nature of public health interventions, including the extent and processes of decision making, reasoning, (...) and justification. There is a need for an ethical framework within pandemic preparedness plans to resolve and avert these problems. (shrink)

“It's more important to look honest than it is to get anything done.” Municipal Agency Commissioner in New York City; Interview, 1991.

DAGFINN FØLLESDAL'S essay in defense of twelve theses on the nature of the noema could be thought of as a spring from which a series of papers continues to flow. The paper's portrayal of the noema as "an intensional entity" has, as Føllesdal notes, "consequences [which] go against the usual interpretation." His "unusual" interpretation has been explored, and continues to be developed, in the flow of papers mentioned as well as in a recent collection that presents itself as a "new (...) approach to Husserl [which] provides an ideal introduction to phenomenology for analytic philosophers.". (shrink)

The purpose of this dissertation is to present and defend a view regarding the freedom of human action which I call "Causationism," a view which incorporates some of the more fundamental commitments of traditional Determinism while allowing for the possibility of statistically regular actions or components of actions. Premise I of Causationism essentially maintains that all human actions are caused either by statistical regularities or deterministically. The inclusion of statistically regular events or components of actions in a causal account is (...) based on an appeal to the Dretske-Snyder thesis of "Causal Irregularity." Premise II of Causationism is essentially identical to the Incompatibility Thesis of traditional Determinism. My theory then proceeds along traditional Deterministic lines, concluding with the claim that "No one is morally responsible for his or her actions." ;Premise I is defended by appeal to empirical evidence. It is then demonstrated that traditional Libertarian arguments intended to weaken the force of this evidence fail. ;In Chapter III, I consider objections to the Incompatibility Thesis. I argue that a hypothetical reading of "he could have done otherwise" not only fails to capture what we mean when we speak of an individual's "acting freely," but also that a hypothetical reading of this phrase fails to provide a sufficient condition for a morally relevant sense of "freedom." ;In Chapter IV, I argue, by appeal to the concept of "novelty" and to Davidson's Mind/Body Theory, that, contrary to the opinion of some philosophers, an event's being caused does not require that it be predictable or subsumable under statements of probability expectations. ;Chapter V addresses the claim that if all actions are caused, then no action can be rational. A variety of arguments are formulated to demonstrate that various versions of the "Determinist Dilemma" fail. ;Finally, in Chapter VI, I argue that adoption of Causationism does not destroy morality although the denial of moral responsibility significantly alters traditional morality and requires a reanalysis of certain basic ethical terms. I offer the required reanalyses and consider the ramifications of their adoption to ethical theory. (shrink)

Argumentation is a form of communication, rather than an application of(formal) logic, and is used in communicative activity as a means forinquiry, although it is more typically thought of as bringing inquiry toclosure. Thus interpretation is an intrinsic and crucial aspect ofconversational (interactive) argumentation. In order to further thisunderstanding of argumentative activity, I propose a procedure forinterpretation that draws upon hermeneutic phenomenology. In response tocriticisms by argumentation theorists (and others) who understand thistradition as oriented to psychological, perceptual, or textual objects, (...) Iargue that hermeneutic phenomenology supports methods for analysis ofpublic communicative activity. The resulting conception of ’thick argumentation‘ responds to contemporary (postmodern) claims that argumentation valorizes univocity, stasis, and certainty at the expense ofthe pluralism, fluctuation, and range of epistemic results thatcharacterize discourse in the public sphere. (shrink)

Current human/social science research supports Don Ihde’s postphenomenology. In particular, archeology and anthropology support Ihde’s instrumental realism, and history identifies the culture that nourished Platonic and Aristotelian separation of mentality and materiality. Deweyean pragmatism, beginning with his analysis of the reflex arc, supports both instrumental realism and an interrelational ontology that rejects the residual Cartesian dualism in Husserlian phenomenology. Ihde’s acknowledgment of the affinity between postphenomenology and Deweyean pragmatism enables expanding his prevalent epistemological and structural orientation to encompass a normative (...) dimension. Peter-Paul Verbeek’s focus on the ethical dimension of how products are designed and how things interact with humans is an important expansion of pragmatic postphenomenology as well as an expansion of current research on the “4e’s” of cognition—embedded, embodied, enacted, and extended—to include a fifth: ethical. (shrink)